The researchers note in The Lancet Neurology that TEV-48125 treatment was also associated with a significant decrease in the use of acute medicines for migraine. However, the team also acknowledges that roles for central and peripheral targets apart from CGRP have been recognized in migraine and therefore concedes that not all individuals with migraine will respond to anti-CGRP therapies. All privileges reserved. Neither of these parties endorse or recommend any commercial products, services, or equipment.. Calcitonin-gene related peptide antibody inhibition shows migraine prevention promise By Lucy Piper, Senior medwireNews Reporter TEV-48125, a monoclonal anti-calcitonin-gene related peptide antibody, is well effective and tolerated in the prevention of high-frequency episodic migraine and chronic migraine, findings from two stage IIb studies show.Dominic ffytcheWhy do we sleep? An interview with Professor Wisden The caspases certainly are a band of enzymes known for leading to cell death, says Associate Professor Bertrand Joseph, who headed the scholarly study. That they also serve as transmission molecules that govern that activity of other cells was an urgent discovery that provides them an entirely new physiological role. By learning cell cultures and mice, the researchers display that certain caspases activate rather than destroy microglial cells, which triggers an inflammatory response.