CYP2J2 implicated in preeclampsia By Nikki Withers, medwireNews Reporter Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression plays a part in preeclampsia. Previous studies have shown that CYP-dependent eicosanoids regulate vascular function, inflammation, and angiogenesis, which are essential in preeclampsia mechanistically, explain Florian Herse and colleagues. They therefore investigated associations between human preeclampsia and CYP epoxygenases. Placental, fat, and muscle mass biopsies were obtained pursuing cesarean sections from 25 preeclamptic women and 23 ladies with normotensive and uncomplicated pregnancies. Related StoriesAngiography and MPI: an interview with Professor Mauro Magnani University of UrbinoUnderstanding the antimicrobial actions of borrelidin: an interview with Dr Min Guo, TSRIKidney failing predictors in adolescents: an interview with Dr.The team, led by Roderic Eckenhoff, MD, Austin Lamont Professor of Anesthesia, exposed mice with individual Alzheimer disease genes, to either anesthesia alone, or anesthesia and an abdominal procedure. The surgery was very similar to appendectomy or colectomy, quite typical procedures in humans. They found that surgery causes a lasting increase in Alzheimer’s pathology, through a transient activation of brain inflammation primarily. Also, a substantial cognitive impairment persisted for at least 14 weeks after surgery in comparison to controls receiving anesthesia by itself. Neither medical procedures nor anesthesia produced changes in normal non-transgenic animals. ‘In the mice, there was a clear and persistent decrement in learning and storage caused by surgery as compared with inhalational anesthesia – but just in the context of a brain produced vulnerable by human being Alzheimer-connected transgenes,’ notes Eckenhoff.